Related Experiment Videos
Mural thrombus in experimental viral myocarditis in mice: relation between thrombosis and congestive heart failure
Abstract:
In a study of the time of appearance of mural thrombus and the relation between thrombosis and congestive heart failure in acute viral myocarditis 180 BALB/c mice were inoculated intraperitoneally with the M variant of encephalomyocarditis virus. Thirty mice were killed on day 5 and 50 mice each on days 7, 10, and 14. Of the 176 mice with myocarditis, 25 (14.2%) developed congestive heart failure after day 9 and 22 (12.5%) showed thrombi after day 6. Most of the thrombi were at the sites of endocardial lesions in the atria. The total incidence of thrombosis in mice with congestive heart failure was significantly higher than that in mice without. None of the 50 uninoculated control mice developed thrombi. The present study suggests that acute viral myocarditis carries an appreciable risk of thromboembolism and that congestive heart failure is a risk factor for thrombosis.
Insights
Acute viral myocarditis increases the risk of thromboembolism. Congestive heart failure in mice with myocarditis was linked to a higher incidence of thrombosis, indicating it
Area of Science:
- Cardiology
- Virology
- Pathology
Background:
- Acute viral myocarditis is a serious cardiac condition.
- Thromboembolism is a known complication of cardiac diseases.
Purpose of the Study:
- To investigate the timing of mural thrombus formation.
- To examine the relationship between thrombosis and congestive heart failure in acute viral myocarditis.
Main Methods:
- 180 BALB/c mice were inoculated with encephalomyocarditis virus.
- Mice were euthanized on days 5, 7, 10, and 14 post-inoculation.
- Incidence of myocarditis, congestive heart failure, and thrombi were recorded.
Main Results:
- 14.2% of mice with myocarditis developed congestive heart failure after day 9.
- 12.5% of mice showed thrombi after day 6, primarily in atrial endocardial lesions.
- Thrombosis incidence was significantly higher in mice with congestive heart failure.
Conclusions:
- Acute viral myocarditis presents a significant risk for thromboembolism.
- Congestive heart failure is identified as a risk factor for thrombosis in this model.