Immunodeficiency associated with motor neuron disease treated with intravenous immunoglobulin

A man with symptoms of amyotrophic lateral sclerosis and immunodeficiency was treated with intravenous immunoglobulin. After four weekly intravenous injections of 2.5 gm of immunoglobulin, his condition showed progressive improvement when measured by clinical, neurological, and physiological parameters. There was a noticeable increase in general physical well-being, an 80% reduction in fasciculations, and the normalization of sensory and motor nerve conduction velocities.