Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oogenesis02:07

Oogenesis

63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

536
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
536
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

406
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
406
Ovarian Cycle01:27

Ovarian Cycle

1.3K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.3K
Menopause01:28

Menopause

174
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
174
Nondisjunction01:21

Nondisjunction

3.9K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pro-EGCG suppresses endometriosis progression via regulating monocytic myeloid-derived suppressor cells.

Chinese medicine·2026
Same author

Comparative performance of traditional and novel adiposity indices for predicting insulin resistance and metabolic syndrome in Chinese women with polycystic ovary syndrome.

Frontiers in nutrition·2026
Same author

The effect of hyoscine N-butylbromide on embryo transfer: a randomized clinical trial.

European journal of obstetrics, gynecology, and reproductive biology·2026
Same author

Sperm-Associated Mercury Species Levels Determine Its Impairment: Evidence from Paired Analyses of Whole Semen and Seminal Plasma.

Biological trace element research·2026
Same author

Aberrant mitochondria in endometriosis: From pathogenic mechanisms to therapeutic opportunities.

iScience·2026
Same author

Serum sPD-L1 Levels in Early Pregnancy Predict Fetal Growth Restriction and Its Subtypes: A Prospective Nested Case-Control Study.

International journal of molecular sciences·2026
Same journal

European society of gynecology (ESG) position paper on the proposed terminology change from PCOS to PMOS.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2026
Same journal

Peripheral precocious puberty with unilateral ovarian agenesis in early childhood: a case report and review of literature.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2026
Same journal

Transdermal versus oral hormone replacement therapy and bone mass density in Turner syndrome patients: a pilot study.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2026
Same journal

Elevated ESR2 and BRCA1 gene expression in adenomyosis associated with endometrial cancer: a pilot study.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2026
Same journal

Progestin therapy in premenopausal women with incidental meningioma-a narrative review and recommendations for women's health specialists.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2026
Same journal

Inter-rater reliability and clinical utility of the modified ferriman-gallwey scale in routine practice.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2026
See all related articles

Related Experiment Video

Updated: Jul 12, 2025

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

1.8K

Is elevated baseline SHBG associated with increased ovulation?

Hui Chang1,2, Hang Ge2, Qi Wu3

  • 1Department of Gynecology I, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
|November 1, 2023
PubMed
Summary
This summary is machine-generated.

Higher levels of Sex Hormone-Binding Globulin (SHBG) predict better ovulation rates in women with Polycystic Ovary Syndrome (PCOS). This finding highlights SHBG

Keywords:
PCOSSHBGovulationpredictionreproductive outcomes

More Related Videos

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.3K
Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

1.1K

Related Experiment Videos

Last Updated: Jul 12, 2025

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

1.8K
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.3K
Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

1.1K

Area of Science:

  • Endocrinology and Reproductive Medicine

Background:

  • Sex Hormone-Binding Globulin (SHBG) is integral to endocrine and reproductive functions.
  • Its specific role in the reproductive processes of women with Polycystic Ovary Syndrome (PCOS) requires further elucidation.

Purpose of the Study:

  • To investigate the predictive value of SHBG levels for ovulation and reproductive outcomes in women with PCOS.
  • To analyze the association between SHBG and other reproductive hormones in relation to ovulation.

Main Methods:

  • Secondary analysis of the PCOSAct clinical trial data involving 954 women with PCOS.
  • Multivariate analysis was used to assess predictors of ovulation, including SHBG, age, BMI, estradiol, and testosterone.
  • Kaplan-Meier curves were utilized to illustrate the relationship between SHBG levels and reproductive success rates.

Main Results:

  • SHBG, age, BMI, estradiol, and testosterone were positive predictors of ovulation (p < 0.05).
  • Higher quartiles of SHBG were significantly associated with increased ovulation rates (HR = 1.138), even after adjusting for testosterone.
  • SHBG demonstrated predictive ability for ovulation, conception, pregnancy, and live birth (p < 0.05), independent of intervention.

Conclusions:

  • Elevated baseline SHBG levels are a significant predictor of successful ovulation and improved reproductive outcomes in women with PCOS.
  • SHBG plays a crucial role in female fertility and warrants consideration in the management of PCOS-related reproductive challenges.