Related Experiment Video

Updated: Jul 12, 2025

Isolation of Lung Retinoid-Containing Cells by Cell Sorting
07:55

Isolation of Lung Retinoid-Containing Cells by Cell Sorting

Published on: April 11, 2025

224

The re-emerging role of linoleic acid in paediatric asthma

Sarah Naughten1, Gertrude Ecklu-Mensah1,2, Gailan Constantino3

  • 1Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.

European Respiratory Review : an Official Journal of the European Respiratory Society
|November 1, 2023
PubMed

Insights

Linoleic acid, common in Western diets, may influence childhood asthma development and severity. Further research is needed to clarify its role in paediatric asthma pathophysiology.

Area of Science:

  • Pediatric Allergy and Immunology
  • Nutritional Immunology
  • Environmental Health

Background:

  • Asthma is a leading chronic childhood illness, influenced by early exposures affecting immune development.
  • Microbial and dietary metabolites are implicated in paediatric asthma onset and exacerbation.
  • Linoleic acid, an omega-6 polyunsaturated fatty acid, is prevalent in Western diets.

Purpose of the Study:

  • To review literature on linoleic acid's role in paediatric asthma development and impact.
  • To explore the relationship between human microbial metabolism and childhood allergic diseases.
  • To examine mechanistic studies on linoleic acid metabolites in asthma.

Main Methods:

  • Literature review of human microbial metabolism and childhood allergic diseases.
  • Analysis of cellular and animal models investigating dietary and microbial linoleic acid metabolites.
  • Synthesis of studies on linoleic acid metabolites in childhood asthma development and exacerbation.

Main Results:

  • Growing evidence suggests a role for linoleic acid in asthma onset and pathophysiology.
  • Conflicting data exists, highlighting the need for further investigation.
  • Microbial and dietary linoleic acid metabolites are key areas of focus.

Conclusions:

  • Linoleic acid metabolites warrant further investigation for their impact on paediatric asthma.
  • Additional cellular, animal, and longitudinal studies are recommended.
  • Targeting linoleic acid and its metabolites may offer future therapeutic avenues.

More Related Videos

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome04:45

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

Published on: June 2, 2022

2.3K
Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

7.7K

Related Concept Videos

Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
324
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
310
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
420
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
765
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K