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Behavioural outcomes of children born with intrauterine growth restriction: protocol for a systematic review and

Ninib Yakoub1, Tilman Reinelt2, Giancarlo Natalucci2

  • 1Family Larsson-Rosenquist Foundation Center for Neurodevelopment, Growth and Nutrition of the Newborn, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland ninib.yakoub@usz.ch.

BMJ Open
|November 1, 2023
PubMed

Insights

Intrauterine growth restriction (IUGR) impacts child behavior, affecting internalizing, externalizing behaviors, and social skills. This review synthesizes evidence on IUGR

Area of Science:

  • Developmental Psychology
  • Perinatal Medicine
  • Child Psychiatry

Background:

  • Intrauterine growth restriction (IUGR) is linked to adverse perinatal outcomes and neurodevelopmental deficits.
  • Existing research suggests IUGR may influence child behavior, including internalizing and externalizing problems and social competencies.
  • A comprehensive synthesis of this evidence, considering moderating factors, is currently lacking.

Purpose of the Study:

  • To systematically review and summarize the association between intrauterine growth restriction (IUGR) and behavioral outcomes in children and young adults.
  • To explore the influence of third variables, such as diagnostic criteria for IUGR, control group selection, and cognitive abilities, on the IUGR-behavior relationship.

Main Methods:

  • A systematic literature search will be conducted across major databases: Web of Science, Medline Ovid, PsycInfo, Cochrane Library, Scopus, and Embase.
  • Inclusion criteria encompass observational and intervention studies quantitatively comparing children (aged 2-18 years) with and without IUGR.
  • Primary outcomes of interest are internalizing behaviors, externalizing behaviors, and social competencies.

Main Results:

  • This section is to be populated upon completion of the review.
  • Anticipated results will quantify the relationship between IUGR and specific behavioral domains.
  • Analysis will investigate how study design and participant characteristics moderate these findings.

Conclusions:

  • The findings will provide a consolidated understanding of IUGR's impact on child and adolescent behavior.
  • Results are expected to inform clinical practice, offering guidance for healthcare professionals and therapists working with IUGR-affected families.
  • This review will highlight areas for future research concerning IUGR and neurodevelopmental trajectories.
Abstract

Keywords:
AdolescentChild & adolescent psychiatryDevelopmental neurology & neurodisabilityPAEDIATRICSPaediatric intensive & critical carePrenatal diagnosis

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