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Muscle Strength Decline Caused by Eperisone Hydrochloride: A Case Report
Junteng Zhu1, Jiecheng Xiao2, Jianxiong Hu3
1Department of Rehabilitation Medicine, Affiliated Hospital of Putian University, Putian, PR China.
Clinical Therapeutics
|November 1, 2023
Summary
Eperisone hydrochloride may cause reversible muscle weakness in patients with incomplete paraplegia. This adverse effect, observed post-surgery, suggests caution when prescribing this muscle relaxant to this patient population.
Area of Science:
- Neurology
- Pharmacology
- Spinal Surgery
Background:
- A 65-year-old female with thoracic spinal stenosis underwent spinal fusion.
- Postoperative rehabilitation included management of neurological deficits.
Observation:
- The patient developed thigh pain, lower limb convulsions, and fatigue.
- Eperisone hydrochloride was administered for symptom relief.
- A significant decrease in muscle strength was noted after 14 doses.
Findings:
- The observed muscle strength decline was reversible upon discontinuation of eperisone hydrochloride.
- This adverse effect is not documented in current Chinese medication instructions.
- Symptoms resolved within 4 days of stopping the medication.
Implications:
- Eperisone hydrochloride may pose a risk of further muscle strength reduction in patients with incomplete paraplegia.
- Clinicians should be aware of this potential adverse effect.
- Medication guidelines for eperisone hydrochloride may require updating to include this risk warning.
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