Virome in immunodeficiency: what we know currently
Hu Wang1, Siqi Xu2,3, Shuang Li1
1Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Chinese Medical Journal
|November 1, 2023
Summary
The human virome significantly impacts health, especially in immunocompromised individuals. Understanding virome alterations offers potential diagnostic and therapeutic benefits for infectious diseases in these vulnerable populations.
Area of Science:
- Human microbiome research
- Virology
- Immunology
Background:
- The human virome, encompassing all viruses in the body, is increasingly recognized for its role in health.
- Immunocompromised individuals face significant health challenges due to increased susceptibility to infections.
Approach:
- This review systematically surveys current literature on virome alterations in various immunodeficiency conditions.
- It analyzes the mechanisms by which virome changes influence disease pathogenesis in immunocompromised hosts.
Key Points:
- Virome composition differs significantly across various immunodeficiency states.
- Specific viral communities can exacerbate disease progression in immunocompromised individuals.
- Mechanisms linking virome dysbiosis to pathogenesis are being elucidated.
Conclusions:
- Understanding the virome is crucial for managing infectious diseases in immunocompromised patients.
- Virome analysis holds promise for novel diagnostic and therapeutic strategies.
- Further research into host-virome interactions is warranted.
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