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Association of LDL-cholesterol subfractions with cardiovascular disorders: a systematic review

Abdolreza Chary1, Maryam Tohidi1, Mehdi Hedayati2

  • 1Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, PO Box: 19395‑4763, Tehran, Iran.

BMC Cardiovascular Disorders
|November 2, 2023
PubMed

Insights

Higher low-density lipoprotein (LDL) particle numbers and small dense LDL are linked to increased cardiovascular disease risk. Evaluating LDL subclasses may aid in diagnosing cardiovascular disorders.

Area of Science:

  • Cardiology
  • Biochemistry
  • Preventive Medicine

Background:

  • Cardiovascular disorders (CVDs) represent the primary global cause of mortality.
  • Understanding risk factors is crucial for effective prevention and treatment strategies.

Conclusions:

  • LDL subclasses show promise as valuable biomarkers for the assessment and diagnosis of cardiovascular diseases.
  • Further research is necessary to elucidate the underlying mechanisms connecting LDL subclasses to CVDs.
Abstract

Keywords:
Cardiovascular DiseaseCholesterolLDL subclassesLow-density lipoproteinSmall dense LDL

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