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Stimuli-Responsive Nanotechnology for RNA Delivery.
Hui Zhou1,2,3, Dean Shuailin Chen2, Caleb J Hu2
1Department of Cardiology, Clinical Trial Center, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 2, 2023
Summary
Stimuli-responsive nanotechnologies enhance RNA drug delivery by protecting RNA, improving cellular uptake, and enabling targeted delivery. These advanced nanoparticles offer a promising path for next-generation RNA medicines.
Area of Science:
- Biotechnology and Nanomedicine
- Molecular Biology and Therapeutics
Background:
- Ribonucleic acid (RNA) drugs offer therapeutic potential by regulating gene expression and protein synthesis.
- Successful clinical translation of RNA medicine, including small interfering RNA (siRNA) and messenger RNA (mRNA) therapies, relies on strategies like chemical modification, ligand conjugation, and nanotechnology.
- Nanotechnology plays a crucial role in protecting RNA from degradation, enhancing cellular uptake and transport, prolonging circulation, and improving targeting.
Purpose of the Study:
- To provide a focused overview of stimuli-responsive nanotechnologies for RNA delivery.
- To highlight the unique benefits of these nanotechnologies in promoting RNA bioactivity and cell/organ selectivity.
- To summarize various stimuli-responsive nanoparticle systems for RNA delivery to facilitate the development of next-generation RNA medicines.
Main Methods:
- Review of internal stimuli-responsive RNA nanoparticles (NPs) utilizing microenvironmental features like pH, enzymes, hypoxia, and redox.
- Review of external stimuli-responsive systems employing light, magnetic fields, and ultrasound for controlled RNA release and transportation.
- Synthesis of information on a wide range of stimuli-responsive NP systems for RNA delivery.
Main Results:
- Stimuli-responsive nanotechnologies demonstrate unique advantages in enhancing RNA drug efficacy and specificity.
- Internal stimuli-responsive NPs leverage specific biological cues for targeted delivery and release.
- External stimuli-responsive systems offer precise control over RNA delivery kinetics and biodistribution.
Conclusions:
- Stimuli-responsive nanotechnologies are crucial for advancing RNA medicine by improving delivery and targeting.
- The integration of internal and external stimuli-responsive strategies holds significant potential for developing highly effective and selective RNA therapeutics.
- This review provides a comprehensive summary of current approaches, paving the way for future innovations in RNA drug delivery.
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