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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

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DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
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Related Experiment Video

Updated: Jul 12, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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[Cardiovascular calcifications in dialysis patients].

Pablo Ureña Torres1,2, Charles Chazot3

  • 1Chef de service de dialyse de l’AURA Nord, Saint-Ouen ; Hôpital Bichat, 12, rue Anselme, 93400 Saint-Ouen, France

Nephrologie & Therapeutique
|November 2, 2023
PubMed
Summary

Cardiovascular calcifications are common in advanced chronic kidney disease and dialysis patients, leading to poor outcomes. Current guidelines for managing this risk are underutilized, necessitating new therapeutic strategies.

Keywords:
calciumcardiovascular diseaseCKD-MBDdialysisphosphatevascular disease

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Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Biology

Background:

  • Patients with advanced chronic kidney disease (CKD) and those on dialysis exhibit a high prevalence of cardiovascular calcifications.
  • These calcifications are linked to severe complications and decreased life expectancy in this vulnerable population.
  • Existing recommendations and imaging scores aim to detect and manage cardiovascular risk, but their practical application remains limited.

Purpose of the Study:

  • To highlight the clinical significance of cardiovascular calcifications in advanced CKD and dialysis patients.
  • To emphasize the gap between current recommendations and clinical practice in managing cardiovascular risk.
  • To explore emerging and evaluated therapeutic strategies for preventing and treating cardiovascular calcifications.

Main Methods:

  • Review of current literature and clinical guidelines on cardiovascular calcifications in CKD and dialysis.
  • Analysis of the challenges in applying existing management strategies.
  • Identification and summary of novel therapeutic approaches under investigation.

Main Results:

  • Cardiovascular calcifications are a major cause of morbidity and mortality in advanced CKD and dialysis patients.
  • Despite established guidelines, the management of cardiovascular risk factors and calcifications is inconsistently applied.
  • Several new therapeutic agents and strategies, including sodium thiosulfate, rheopheresis, vitamin K, magnesium, and SNF-472, are being evaluated.

Conclusions:

  • Effective prevention and treatment of cardiovascular calcifications require addressing traditional atherosclerosis risk factors, mineral and bone disorders, and optimizing dialysis.
  • There is a critical need for improved adherence to current guidelines and the development of novel therapies.
  • Emerging treatments show promise for mitigating the burden of cardiovascular calcifications in CKD and dialysis populations.