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Health state utility values for children and adolescents with type 1 diabetes: A systematic review and meta-analysis

Shitong Xie1,2, Meixuan Li3, Xin Chen1

  • 1School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.

Diabetic Medicine : a Journal of the British Diabetic Association
|November 2, 2023
PubMed

Insights

Health utility values for children and adolescents with type 1 diabetes mellitus (T1DM) were analyzed, revealing an overall utility of 0.91. Complications lowered utility, while younger children reported higher values than adolescents.

Area of Science:

  • Health Economics
  • Pediatric Endocrinology
  • Quality of Life Research

Background:

  • Type 1 diabetes mellitus (T1DM) represents a significant global health burden.
  • Health utility values are crucial for quantifying disease impact and cost-utility analyses.
  • This review established reference health utility values for pediatric and adolescent T1DM populations.

Approach:

  • Systematic literature search of MEDLINE and Embase up to March 2023.
  • Inclusion of studies measuring health utility values in individuals aged 18 years or younger with T1DM.
  • Meta-analysis and subgroup analyses to assess variations by population characteristics and measurement methods.

Key Points:

  • Pooled meta-analysis of six studies (1276 participants) yielded an overall T1DM utility value of 0.91.
  • Individuals with T1DM complications had lower utility (0.90) than those without (0.96).
  • Utility values varied by age (children 0.90 vs. adolescents 0.85) and measurement tool (EQ-5D-3L: 0.91, HUI3: 0.89, SF-6Dv1: 0.83, TTO: 0.81).

Conclusions:

  • A reference set of pooled utility estimates for pediatric and adolescent T1DM was developed.
  • These values aid in understanding T1DM's overall health status and conducting economic evaluations.
  • Further research is recommended to investigate utilities associated with specific T1DM complications.
Abstract

Keywords:
adolescentschildrenhealth utilitymeta-analysissystematic reviewtype 1 diabetes

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