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Epidemiology of arrhythmogenic ventricular cardiomyopathy in China

Si-Tong Liu1, Rui Li2, Jian-Peng Zheng3

  • 1Cardiovascular Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Clinical Cardiology
|November 2, 2023
PubMed

Insights

Arrhythmogenic ventricular cardiomyopathy (AVC) incidence in China has doubled, rising by 8.9% annually. While males and females show similar ventricular tachycardia and mortality rates, males experience lower heart failure rates, possibly due to RFA use.

Area of Science:

  • Cardiology
  • Epidemiology
  • Genetics

Background:

  • Arrhythmogenic ventricular cardiomyopathy (AVC) is a significant cause of ventricular arrhythmias and mortality.
  • Limited epidemiological data exists for AVC in large Asian cohorts, particularly the Chinese population.

Purpose of the Study:

  • To investigate the current status and epidemiological trends of AVC in China.
  • To determine the incidence of ventricular tachycardia (VT), heart failure (HF), and mortality in Chinese patients with AVC.

Main Methods:

  • Analysis of 15,888 adults from the BMHCIC registry database (2010-2020).
  • Calculation of average annual percentage change (AAPC) for AVC incidence.
  • Comparison of VT, HF, and mortality rates between male and female AVC patients.

Main Results:

  • AVC incidence increased significantly from 7.60 to 19.62 per 1000 person-years between 2010 and 2020 (AAPC 8.9%).
  • Males exhibited a higher incidence of AVC compared to females.
  • While VT prevalence and mortality were similar, males had lower HF prevalence than females, with RFA more common in males.

Conclusions:

  • A clear rising trend in AVC incidence in China was observed, with a two-fold increase by 2020.
  • Male AVC patients demonstrated similar VT prevalence and mortality but lower HF prevalence compared to females.
  • Radiofrequency ablation (RFA) may influence the lower HF prevalence observed in male AVC patients.
Abstract

Keywords:
Chinese populationarrhythmogenic ventricular cardiomyopathyepidemiology

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