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Updated: Jul 12, 2025

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Exploring the Association between Thyroid Function and Frailty: Insights from Representative Korean Data.

Youn-Ju Lee1,2, Min-Hee Kim3, Dong-Jun Lim4

  • 1Department of Biostatistics, Korea University College of Medicine, Seoul, Korea.

Endocrinology and Metabolism (Seoul, Korea)
|November 2, 2023
PubMed
Summary
This summary is machine-generated.

Thyroid dysfunction, especially hyperthyroidism, is linked to frailty in older adults. This study highlights the importance of monitoring thyroid health to prevent frailty in the elderly population.

Keywords:
AgedFrailtyThyroidThyroid function tests

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Area of Science:

  • Gerontology
  • Endocrinology
  • Public Health

Background:

  • Frailty is a growing concern in aging populations.
  • Thyroid dysfunction is common in older adults and can affect various bodily functions.
  • Understanding the link between thyroid health and frailty is crucial for geriatric care.

Purpose of the Study:

  • To investigate the association between thyroid function and frailty in individuals aged 50 and older.
  • To analyze how different types of thyroid dysfunction relate to the prevalence of frailty.
  • To identify specific thyroid function parameters associated with increased frailty risk.

Main Methods:

  • Utilized data from the Korea National Health and Nutrition Examination Survey (2013-2015).
  • Included 2,416 participants aged 50+ with thyroid function tests.
  • Assessed frailty using the Fried frailty phenotype criteria.

Main Results:

  • Overt and subclinical hyperthyroidism showed a significant association with frailty.
  • Higher free thyroxine (FT4) levels were linked to increased frailty risk in hyperthyroid individuals.
  • In overt hypothyroidism, lower FT4 and higher TSH levels were associated with frailty.

Conclusions:

  • Thyroid dysfunction, particularly hyperthyroidism, is associated with an increased risk of frailty in older adults.
  • These findings underscore the importance of thyroid function assessment in the elderly.
  • Further research may explore interventions targeting thyroid health to mitigate frailty.