Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

5.6K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.6K
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

4.1K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
4.1K
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

1.9K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
1.9K
Inhaled Medications01:23

Inhaled Medications

287
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
287
Health Information Technology and Healthcare Information System01:30

Health Information Technology and Healthcare Information System

847
Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
847
Errors occurring during blood pressure monitoring01:25

Errors occurring during blood pressure monitoring

740
Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
740

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An overview of hedgehog signaling in fibrosis.

Molecular pharmacology·2014
Same author

Enhanced utility of family-centered diagnostic exome sequencing with inheritance model-based analysis: results from 500 unselected families with undiagnosed genetic conditions.

Genetics in medicine : official journal of the American College of Medical Genetics·2014
Same author

Therapeutic imaging window of cerebral infarction revealed by multisequence magnetic resonance imaging: An animal and clinical study.

Neural regeneration research·2014
Same author

Microwave synthesis of microstructured and nanostructured metal chalcogenides from elemental precursors in phosphonium ionic liquids.

Journal of the American Chemical Society·2014
Same author

Cr(VI) reduction and Cr(III) immobilization by Acinetobacter sp. HK-1 with the assistance of a novel quinone/graphene oxide composite.

Environmental science & technology·2014
Same author

Resveratrol inhibits epithelial-mesenchymal transition and renal fibrosis by antagonizing the hedgehog signaling pathway.

Biochemical pharmacology·2014

Related Experiment Video

Updated: Jul 12, 2025

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

18.9K

Precision Dosing Management with Intelligent Computing in Digital Health.

Hong Lu1, Sara Rosenbaum2, Wei Lu3

  • 1Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto ON Canada.

Proceedings. International Conference on Intelligent Networking and Collaborative Systems
|November 2, 2023
PubMed
Summary

Optimizing pediatric drug dosing requires understanding how growth affects pharmacokinetics and pharmacodynamics. This study introduces an intelligent computing framework to improve pediatric dose finding and treatment efficacy.

More Related Videos

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.2K
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.3K

Related Experiment Videos

Last Updated: Jul 12, 2025

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

18.9K
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.2K
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.3K

Area of Science:

  • Pharmacology
  • Pediatric Drug Development
  • Computational Biology

Background:

  • Pediatric dosing is critical for drug development, patient safety, and effective clinical treatment.
  • Children exhibit complex pharmacokinetics, posing challenges for precise dosing during drug development and clinical practice.
  • Understanding age- and size-dependent dose-exposure-response relationships is essential for optimizing pediatric medication.

Purpose of the Study:

  • To propose a novel intelligent computing framework for analyzing pediatric pharmacokinetics and pharmacodynamics.
  • To examine the impact of growth and maturation on size- and age-dependent variability in drug disposition and effects.
  • To summarize modeling-based approaches for pediatric dose finding.

Main Methods:

  • Development of an intelligent computing framework.
  • Analysis of growth and maturation effects on pharmacokinetic and pharmacodynamic variability.
  • Review of modeling-based strategies for pediatric dose optimization.

Main Results:

  • The framework facilitates examination of size- and age-dependent variability in pediatric pharmacokinetics and pharmacodynamics.
  • Modeling-based approaches aid in optimizing pediatric dosing regimens.
  • Anticipation of treatment effects and improved likelihood of achieving optimal doses.

Conclusions:

  • The proposed framework and modeling approaches enhance pediatric dose finding.
  • Clinicians can better anticipate treatment effects and achieve optimal dosing regimens.
  • Reduced drug development timelines and costs are achievable through optimized pediatric dosing strategies.