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Radiotherapy for Non-Hodgkin's lymphoma with cardiac infiltration: A case report
Weifeng Wang1, Zhuo Zhang1, Xiaocong Deng1
1Department of Radiation Oncology, Hainan Cancer Hospital, Haikou, China.
Background:
Non-Hodgkin's lymphoma (NHL) with cardiac infiltration has a poor prognosis. The median OS of patients failing to respond to chemotherapy has been reported to be 1 month vs. 18 months in patients responding to chemotherapy.
Case Presentation:
Herein, we reported a case of a 57-year-old male confirmed with diffuse large B-cell lymphoma who received radiation therapy of 150-cGy daily, administered in 30 fractions to the volume of cardiac infiltration, resulting in complete relief. Chemotherapy had no curative effect. The patient was subsequently enrolled in a clinical trial and received oral administration of zanubrutinib 80mg twice daily, after which he achieved complete remission. The progression-free survival was from diagnosis (January 7, 2020) to the follow-up (September 20, 2022), amounting to 32 months.
Conclusion:
Proper irradiation dose and timing of treatment can relieve NHL symptoms.
