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LncRNA polymorphisms and lung cancer risk.
Esmat Abdi1, Saeid Latifi-Navid1, Alireza Panahi1
1Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 5619911367, Iran.
Personalized Medicine
|November 2, 2023
Summary
Genetic variations in long non-coding RNAs (lncRNAs) significantly impact lung cancer (LC) development and treatment outcomes. Understanding these lncRNA polymorphisms may help predict cancer risk and personalize therapy for lung cancer patients.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Lung cancer (LC) is a leading cause of cancer-related mortality worldwide.
- Aberrant expression of long non-coding RNAs (lncRNAs) is frequently observed in LC.
- lncRNA genetic polymorphisms can alter their expression and function, influencing cancer progression.
Purpose of the Study:
- To provide a comprehensive overview of the impact of lncRNA genetic polymorphisms on lung cancer.
- To explore the potential of lncRNA variants in predicting LC risk and treatment responses.
Main Methods:
- Literature review and synthesis of existing research on lncRNA polymorphisms and lung cancer.
- Analysis of how these polymorphisms affect cancer development, patient survival, chemotherapy response, and recurrence.
Main Results:
- lncRNA genetic polymorphisms are associated with altered expression levels and structural dysfunction.
- These variations can influence key aspects of lung cancer, including progression, survival, and treatment efficacy.
- lncRNA variants show potential as biomarkers for predicting cancer risk and therapeutic outcomes.
Conclusions:
- lncRNA genetic polymorphisms play a crucial role in lung cancer pathogenesis and clinical outcomes.
- Further large-scale, diverse ethnic studies are needed to validate these findings.
- Personalized lung cancer therapy based on lncRNA genotypes is a promising future direction.
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