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Related Experiment Videos

Inbreeding and schizophrenia.

L Saugstad, O Odegård

    Clinical Genetics
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    This study found no significant correlation between consanguinity and psychiatric hospital admissions in Norway, suggesting selective mating practices. Changes in diagnostic criteria and treatments likely explain shifts in psychosis diagnoses over time.

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    Psychological medicine·1986

    Area of Science:

    • Psychiatry
    • Medical History
    • Epidemiology

    Background:

    • Utilized unique Norwegian census data (1891) on consanguinity and psychiatric hospital admission records (1921-1940).
    • Investigated potential links between inbreeding patterns and psychiatric admission rates in rural communities.
    • Examined changes in psychiatric diagnoses, particularly schizophrenia, over the 20th century.

    Purpose of the Study:

    • To determine if consanguinity correlates with psychiatric hospital admission rates.
    • To explore factors influencing marriage patterns and their relation to psychiatric health.
    • To analyze trends in psychiatric diagnoses and their potential causes.

    Main Methods:

    • Comparative analysis of historical census data on spousal relationships and hospital admission records.

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  • Statistical examination of inbreeding patterns and admission rates.
  • Review of diagnostic trends and treatment changes in psychiatry.

    • Main Results:

    • No significant correlation found between consanguinity and psychiatric admission rates, attributed to selective mate choice.
    • Lower-than-expected first cousin marriages among parents of psychiatric patients suggest reduced morbidity in offspring.
    • Significant diagnostic shifts observed, with a decline in functional psychoses like schizophrenia and disappearance of catatonia/hebephrenia.

    Conclusions:

    • Selective avoidance in marriage partners likely mitigates genetic risks associated with consanguinity.
    • Changes in diagnostic practices, not incidence rates, explain the decline in schizophrenia diagnoses.
    • Psychotropic drugs and improved treatments may account for the disappearance of catatonia and hebephrenia.