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Genome editing-induced t(4;11) chromosomal translocations model B cell precursor acute lymphoblastic leukemias with
Feng Pan1,2, Jolanda Sarno3,4, Johan Jeong1
1Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
The Journal of Clinical Investigation
|November 2, 2023
Abstract:
A t(4;11) leukemia model established from CRISPR-engineered chromosomal translocations between the KMT2A and AFF1 genes recapitulate proteomic, epigenomic, and transcriptomic features of primary patient leukemias.
