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Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

A modified scleroderma skin scoring method.

M B Kahaleh, G L Sultany, E A Smith

Clinical and Experimental Rheumatology

|October 1, 1986

Summary

Skin thickness in scleroderma correlates with internal organ involvement. A new objective skin scoring method shows good reproducibility for monitoring disease activity in scleroderma patients.

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Area of Science:

Rheumatology
Dermatology
Medical Diagnostics

Background:

Skin thickness in scleroderma is linked to internal organ involvement.
Objective assessment of skin involvement is needed for disease management.

Purpose of the Study:

To describe and evaluate an objective method for assessing skin involvement in scleroderma.
To determine the inter-observer reproducibility of this new skin scoring method.

Main Methods:

A preliminary study involving twenty scleroderma patients.
Development and testing of an objective clinical evaluation method for skin involvement (skin score).

Main Results:

The proposed skin scoring method demonstrated an acceptable degree of inter-observer reproducibility.
The method provides an objective measure for evaluating skin changes in scleroderma.

Conclusions:

The objective skin score is a reliable tool for assessing skin involvement in scleroderma.
This method can be utilized for monitoring disease progression and overall activity in scleroderma patients.

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