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Updated: Jul 12, 2025
12:08
Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
Published on: May 22, 2013
46.6K
T-cell lymphocytes' aging clock: telomeres, telomerase and aging
Alain Chebly1,2, Charbel Khalil3,4,5, Alexandra Kuzyk6
1Jacques Loiselet Center for Medical Genetics and Genomics (CGGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon. alain.chebly@usj.edu.lb.
Biogerontology
|November 2, 2023
Summary
Aging impacts human immune cells, specifically T-cells. This review examines the roles of telomeres and telomerase in T-cell aging and related diseases, highlighting their significance in immune system decline.
Area of Science:
- Immunology
- Gerontology
- Molecular Biology
Background:
- Aging is a natural process involving physiological decline.
- Immune cells, particularly T-cells, undergo significant aging-related alterations.
- Telomeres and telomerase are key factors in cellular aging and function.
Purpose of the Study:
- To comprehensively review the literature on T-cell telomeres and telomerase.
- To explore the roles of telomeres and telomerase in T-cell aging.
- To understand the connection between telomere length, telomerase activity, and age-related diseases.
Main Methods:
- Literature review of scientific articles.
- Analysis of studies on T-cell differentiation and aging.
- Examination of research linking telomeres/telomerase to T-cell malignancies and diseases.
Main Results:
- Telomeres shorten with T-cell aging.
- Telomerase activity is linked to T-cell differentiation and proliferation.
- Short telomeres and telomerase activation are observed in T-cell malignancies.
Conclusions:
- Telomeres and telomerase are critical determinants of T-cell aging.
- Dysregulation of telomeres and telomerase contributes to age-related immune dysfunction.
- Further research into telomere biology may offer insights into treating age-related diseases.
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