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Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Risk and Prognostics of Second Primary Cancer After Prostate Radiation Therapy.

Elisa K Liu1, Thomas B Daniels1, Jonathan W Lischalk2

  • 1Department of Radiation Oncology, NYU Grossman School of Medicine, New York, New York.

Urology Practice
|November 2, 2023
PubMed
Summary
This summary is machine-generated.

Radiation therapy for prostate cancer may increase the risk of secondary pelvic malignancies, but the absolute risk remains very low. Developing a secondary cancer impacts survival, particularly in younger patients.

Keywords:
prostate radiationradiation induced cancerssecondary malignancy

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Cancer Epidemiology

Background:

  • Prostate cancer survival is improving, necessitating understanding of long-term treatment side effects.
  • The risk of secondary cancers after prostate cancer treatment, especially in older adults, requires further investigation.

Purpose of the Study:

  • To assess the incidence of second primary pelvic malignancies (SPPMs) after prostate cancer diagnosis.
  • To evaluate the impact of radiation therapy on SPPM development and overall survival.

Main Methods:

  • Analysis of 569,167 prostate cancer cases from 1975-2016 using Surveillance, Epidemiology, and End Results data.
  • Fine-Gray competing risk models and time-varying Cox proportional hazard models were used.
  • Risk of SPPMs and association with mortality were assessed, controlling for patient and treatment factors.

Main Results:

  • Radiation therapy was associated with a higher incidence of SPPMs (1.8% vs 1.1% at 25 years).
  • Developing an SPPM significantly worsened survival (aHR=1.76), especially in patients under 63 (aHR=2.36).
  • A total of 4956 SPPMs were identified among the study population.

Conclusions:

  • While radiation therapy may increase SPPM risk, the absolute risk is low.
  • Secondary malignancies negatively affect overall survival, with a more pronounced effect in younger patients.