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Updated: Jul 11, 2025

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Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
Published on: September 22, 2020
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The Jewish Perspectives on Xenotransplantation.
John D Loike1,2, Rabbi Moshe Krupka3
1Co-Director of Bioethics, New York Medical College, Valhalla, New York, USA.
Rambam Maimonides Medical Journal
|November 2, 2023
Summary
Jewish perspectives on xenotransplantation suggest that saving a life outweighs religious concerns. However, specific religious nuances require scholarly attention for ethical organ transplantation. This review explores these considerations.
Area of Science:
- Medical Ethics
- Religious Studies
- Transplantation Surgery
Background:
- The critical shortage of human organ donors necessitates alternative solutions like xenotransplantation.
- Genetically engineered pigs are a primary focus for xenotransplantation due to biological similarities.
- Religious objections, particularly from Judaism and Islam, pose challenges to pig-based xenotransplantation.
Purpose of the Study:
- To examine Jewish religious perspectives on the practice of xenotransplantation.
- To identify potential conflicts between Jewish law and xenotransplantation procedures.
- To explore how religious concerns can be addressed within the framework of preserving human life.
Main Methods:
- Review of relevant Jewish legal and ethical texts.
- Analysis of rabbinical responsa concerning medical interventions and animal use.
- Comparative study of religious principles and xenotransplantation practices.
Main Results:
- The principle of preserving human life (Pikuach Nefesh) generally overrides other religious prohibitions in Jewish law.
- Specific concerns exist regarding the use of pigs, including dietary laws and commercial restrictions.
- There is a recognized need for rabbinical guidance to navigate these complex ethical and religious issues.
Conclusions:
- Xenotransplantation, while facing religious considerations, is permissible under Jewish law when necessary to save a life.
- Rabbinical scholars must address the specific religious nuances to ensure ethical implementation.
- The ethical framework supports xenotransplantation, emphasizing the paramount importance of human life.
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