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Published on: January 18, 2017
Aspirin in Pregnancy
Maura Jones Pullins1, Kim Boggess, T Flint Porter
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and the Division of Maternal-Fetal Medicine, Intermountain Healthcare, Salt Lake City, Utah.
Insights
Aspirin is recommended for preeclampsia prevention in high-risk pregnancies. This review examines aspirin
Area of Science:
- Obstetrics and Gynecology
- Perinatal Medicine
- Pharmacology
Background:
- Preeclampsia poses significant risks to perinatal health.
- Aspirin is widely studied for preeclampsia prevention.
- Current guidelines on aspirin use in pregnancy vary globally.
Conclusions:
- Aspirin is a key intervention for preeclampsia prevention in at-risk pregnancies.
- Further research is needed to standardize optimal aspirin use protocols.
- Understanding aspirin's broader applications in pregnancy is crucial.
Abstract:
Preeclampsia is associated with significant perinatal morbidity and mortality. Aspirin has been long purported and extensively studied for prevention of preeclampsia. For this reason, the U.S. Preventive Services Task Force, the American College of Obstetricians and Gynecologists, and the Society for Maternal-Fetal Medicine recommend its use in pregnancy for preeclampsia prevention in those at high risk. Yet, much controversy exists regarding optimal use in pregnancy with guidelines across global organizations varying. In this narrative review, we summarize the published literature related to the safety, optimal dose, and timing and duration of use of aspirin, as well as other indications for which aspirin has been studied in pregnancy.
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