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Chronic Hypertension and the Risk of Readmission for Postpartum Cardiovascular Complications
Emily B Rosenfeld1, Justin S Brandt, Jessica C Fields
1Division of Maternal-Fetal Medicine and the Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences, the Cardiovascular Institute of New Jersey, and the Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, and the Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey; the Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, NYU Langone Health, New York, New York; and the Clinical Epidemiology Division, Faculty of Medicine at Solna, Karolinska Institutet, Stockholm, Sweden.
Insights
Chronic hypertension during pregnancy significantly increases the risk of cardiovascular disease (CVD) complications within a year after delivery. This highlights the need for postpartum monitoring to manage blood pressure and prevent heart disease and stroke.
Area of Science:
- Obstetrics and Gynecology
- Cardiology
- Public Health
Background:
- Preeclampsia is a known risk factor for long-term cardiovascular disease (CVD).
- The impact of chronic hypertension without preeclampsia on immediate postpartum CVD risk is not well understood.
Purpose of the Study:
- To assess the risk of readmission for CVD complications within one year postpartum among individuals with chronic hypertension.
- To investigate the association between chronic hypertension during pregnancy and postpartum CVD events.
Main Methods:
- Retrospective cohort study using the Nationwide Readmission Database (2010-2018).
- Included singleton births, identified chronic hypertension and CVD readmissions using ICD codes.
- Excluded preeclampsia, eclampsia, multiple births, and pre-existing CVD.
Main Results:
- 2.0% of deliveries involved individuals with chronic hypertension.
- Chronic hypertension was associated with a significantly higher rate of CVD readmission (645 vs. 136 per 100,000 deliveries).
- The elevated CVD risk persisted up to one year postpartum.
Conclusions:
- Chronic hypertension in pregnancy elevates CVD risk in the early postpartum period.
- Close postpartum monitoring and timely interventions are crucial for managing blood pressure and preventing CVD complications.
Objective:
Preeclampsia is an important risk factor for cardiovascular disease (CVD, including heart disease and stroke) along the life course. However, whether exposure to chronic hypertension in pregnancy, in the absence of preeclampsia, is implicated in CVD risk during the immediate postpartum period remains poorly understood. Our objective was to estimate the risk of readmission for CVD complications within the calendar year after delivery for people with chronic hypertension.
Methods:
The Healthcare Cost and Utilization Project's Nationwide Readmission Database (2010-2018) was used to conduct a retrospective cohort study of patients aged 15-54 years. International Classification of Diseases codes were used to identify patients with chronic hypertension and postpartum readmission for CVD complications within 1 year of delivery. People with CVD diagnosed during pregnancy or delivery admission, multiple births, or preeclampsia or eclampsia were excluded. Excess rates of CVD readmission among patients with and without chronic hypertension were estimated. Associations between chronic hypertension and CVD complications were determined from Cox proportional hazards regression models.
Results:
Of 27,395,346 delivery hospitalizations that resulted in singleton births, 2.0% of individuals had chronic hypertension (n=544,639). The CVD hospitalization rate among patients with chronic hypertension and normotensive patients was 645 (n=3,791) per 100,000 delivery hospitalizations and 136 (n=37,664) per 100,000 delivery hospitalizations, respectively (rate difference 508, 95% CI 467-549; adjusted hazard ratio 4.11, 95% CI 3.64-4.66). The risk of CVD readmission, in relation to chronic hypertension, persisted for 1 year after delivery.
Conclusion:
The heightened CVD risk as early as 1 month postpartum in relation to chronic hypertension underscores the need for close monitoring and timely care after delivery to reduce blood pressure and related complications.
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