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Cross-modal associative memory impairment in schizophrenia
Tianhao Gao1, Xiaoliang Wang2, Haixin Cen2
1Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai, 200040, China; Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China; Clinical Center for Psychotic Disorders, National Center for Mental Disorders, Shanghai, 200030, China.
Neuropsychologia
|November 2, 2023
Summary
Schizophrenia patients show impaired associative memory, especially when integrating visual and auditory information. This cross-modal deficit correlates with negative symptom severity, highlighting a key cognitive challenge.
Area of Science:
- Cognitive Neuroscience
- Psychiatry
Background:
- Associative memory impairments are common in schizophrenia.
- Previous research focused on unisensory processing, limiting understanding of multi-sensory integration deficits.
Purpose of the Study:
- To investigate associative memory in schizophrenia across visual and auditory domains.
- To examine both unisensory and cross-modal associative memory performance.
Main Methods:
- 32 schizophrenia patients and 29 healthy controls completed auditory-auditory, auditory-visual, and visual-visual associative memory tasks.
- Discriminability scores were calculated and compared between groups.
Main Results:
- Schizophrenia patients exhibited associative memory deficits in both same- and cross-modal tasks.
- Cross-modal associative memory was significantly impaired in schizophrenia patients compared to controls (t = 4.120, p < 0.001).
- Impaired cross-modal associative memory negatively correlated with negative symptom severity (r = -0.362, p = 0.042).
Conclusions:
- Schizophrenia involves abnormalities in processing integrated multi-sensory information.
- Findings suggest cross-modal associative memory deficits are a significant cognitive symptom in schizophrenia.
- Results may inform future interventions for cognitive dysfunction in schizophrenia.
Keywords:
Cross-modal associative memoryNegative symptomsSame-modality associative memorySchizophreniaMore Related Videos
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