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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Positron Emission Tomography01:29

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Related Experiment Video

Updated: Jul 11, 2025

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
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Quantitative Perfusion Imaging with Total-Body PET.

Juhani Knuuti1,2, Jouni Tuisku3, Henri Kärpijoki3

  • 1Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland; juhani.knuuti@utu.fi.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|November 2, 2023
PubMed
Summary
This summary is machine-generated.

Total-body PET scanners offer new research avenues by imaging all organs simultaneously. Quantitative perfusion imaging using 15O-water shows promise for multisystem analysis in clinical diagnostics and research.

Keywords:
PETPET/CTperfusionquantitationradiotracer tissue kineticstotal-body imaging

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Area of Science:

  • Nuclear medicine
  • Medical imaging
  • Physiology

Background:

  • Long axial field-of-view PET systems represent the state-of-the-art in imaging technology.
  • Total-body PET scanners unlock novel research and clinical diagnostic capabilities, alongside significant technical challenges.

Approach:

  • This review focuses on total-body quantitative perfusion imaging, a promising technique utilizing 15O-labeled water for whole-body tissue perfusion assessment.
  • It summarizes current methodologies, analytical approaches, and preliminary findings from multisystem applications.

Key Points:

  • Simultaneous imaging of all organs in the field of view enables the study of biological interactions across the entire body.
  • Quantitative parametric perfusion imaging provides a powerful tool for both research and clinical applications.
  • The shift from single-organ to multisystem modeling presents unique opportunities and challenges in data analysis and interpretation.

Conclusions:

  • Total-body PET imaging, particularly quantitative perfusion imaging, is a rapidly advancing field with significant potential for understanding systemic physiology and disease.
  • Future directions involve refining multisystem modeling and exploring broader clinical applications of this technology.