Related Experiment Video

Updated: Jul 11, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

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Caveolin-1 mediates the utilization of extracellular proteins for survival in refractory gastric cancer

Nahee Hwang1,2,3, Bo Kyung Yoon1,3, Kyu-Hye Chun1,2,3

  • 1Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Experimental & Molecular Medicine
|November 3, 2023
PubMed

Insights

Chemoresistant gastric cancer cells depend on caveolin-1 for survival via endocytosis. Inhibiting this process, using drugs like chloroquine, suppressed tumor growth, revealing a new therapeutic target.

Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Gastric cancer poses a significant clinical challenge due to tumor heterogeneity and poor patient outcomes.
  • Identifying vulnerabilities in chemoresistant gastric cancer subtypes is critical for developing effective therapies.

Purpose of the Study:

  • To investigate the survival mechanisms of chemoresistant gastric cancer cells.
  • To identify potential therapeutic targets for refractory gastric cancer.

Main Methods:

  • Analysis of caveolin-1 expression in gastric cancer cells.
  • Investigating the role of caveolin-1-mediated endocytosis in cell survival.
  • Evaluating the efficacy of lysosomal inhibitors (e.g., chloroquine) in vitro and in vivo.

Main Results:

  • Caveolin-1 is upregulated in stem-like/EMT/mesenchymal (SEM)-type gastric cancer cells.
  • Caveolin-1 facilitates endocytosis and utilization of extracellular proteins for survival.
  • Downregulating caveolin-1 induces cell death in SEM-type gastric cancer cells.
  • Chloroquine blocks caveolin-1-mediated endocytosis and suppresses tumor growth in vitro and in vivo.

Conclusions:

  • Caveolin-1-mediated endocytosis is a crucial survival pathway for chemoresistant gastric cancer.
  • Targeting caveolin-1-mediated endocytosis presents a promising therapeutic strategy for gastric cancer.

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