Associations between apolipoprotein B and bone mineral density: a population-based study

Area of Science:

• Bone metabolism and lipidology
• Skeletal health and cardiovascular risk factors

Background:

• Lipids play a crucial role in bone metabolism.
• Understanding lipid profiles, including apolipoprotein B (apo B), is vital for bone health.
• Previous research indicates the importance of lipids in bone metabolism.

Purpose of the Study:

• To investigate the relationship between apolipoprotein B (apo B) and bone mineral density (BMD).
• To examine BMD at the lumbar spine, femoral neck, and total femur.
• To compare apo B's influence on BMD with traditional lipid markers.

Main Methods:

• Utilized data from the National Health and Nutrition Examination Survey (NHANES) (2011-2016).
• Included participants with complete data for apo B and BMD at three skeletal sites.
• Employed weighted multivariate regression, subgroup analysis, interaction tests, and restricted cubic spline (RCS) for association and non-linear relationship analysis.

Main Results:

• Analyzed data from 4,258 adults.
• Found a negative association between apo B and lumbar spine BMD (β = -0.054).
• Observed a positive association between apo B and femoral neck BMD (β = 0.031), with no significant link to total femur BMD.

Conclusions:

• Apolipoprotein B (apo B) demonstrates a site-specific association with bone mineral density (BMD).
• The findings suggest differential impacts of apo B on various skeletal sites.