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EaveTubes for control of vector-borne diseases in Côte d'Ivoire: study protocol for a cluster randomized controlled
Raphael N'Guessan1, Serge-Brice Assi1, Alphonsine Koffi1
1Vector Control Product Evaluation Centre/Institut Pierre Richet, Bouaké, Côte d'Ivoire.
Trials
|November 3, 2023
Summary
This study evaluates In2Care® EaveTubes (ETs) as a novel malaria prevention tool in Côte d'Ivoire. The research assesses ETs' impact on clinical malaria incidence and vector populations in areas with insecticide resistance.
Area of Science:
- Public Health Entomology
- Infectious Disease Epidemiology
- Vector-Borne Disease Control
Background:
- Insecticide resistance in malaria vectors significantly reduces the effectiveness of traditional tools like long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS).
- New vector control strategies are crucial for continued progress in malaria prevention.
- In2Care® EaveTubes (ETs) represent a novel, resistance-breaking product designed to target malaria vectors by leveraging natural mosquito behavior and airflow.
Purpose of the Study:
- To evaluate the efficacy of In2Care® EaveTubes (ETs) as a standalone intervention against clinical malaria incidence.
- To assess the impact of ETs on malaria vector densities and sporozoite rates in a high-transmission area.
- To provide data for the World Health Organization Vector Control Advisory Group (VCAG) assessment of ETs' public health value.
Main Methods:
- A two-armed, cluster randomized controlled trial involving 34 villages in Côte d'Ivoire.
- Intervention arm: Houses treated with ETs combined with LLINs; Control arm: LLINs only.
- Clinical malaria incidence tracked in children aged 6 months to 8 years over 24 months; entomological surveys conducted monthly.
Main Results:
- The study is designed as an efficacy trial; results are pending.
- Entomological outcomes will be measured to infer impact on malaria transmission dynamics.
- Data will inform the public health value assessment by the WHO VCAG.
Conclusions:
- The findings will determine the efficacy of ETs as a standalone malaria vector control tool.
- Results will contribute to the development of guidelines for evaluating new vector control products.
- This research aims to support the potential integration of ETs into malaria prevention strategies.
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