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Updated: Jul 11, 2025
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
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Interactions between neutrophils and T-helper 17 cells
Xinzou Fan1, Panyin Shu1, Ying Wang2
1Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in Immunology
|November 3, 2023
Summary
This review explores the critical roles of neutrophils and T-helper 17 (Th17) cells in immunity and disease. It highlights their interactions and therapeutic targets, particularly those involving interleukin 17 (IL-17).
Area of Science:
- Immunology
- Cell Biology
Background:
- Neutrophils are abundant immune cells crucial for innate immunity against infections, autoimmunity, and cancer.
- T-helper 17 (Th17) cells, producing interleukin 17 (IL-17), are vital for fighting infections and maintaining mucosal homeostasis but also implicated in autoimmune diseases.
Purpose of the Study:
- To review the physiological roles and interactions of neutrophils and Th17 cells.
- To discuss their involvement in various pathological processes.
- To summarize drugs targeting IL-17A and related clinical trials.
Main Methods:
- Literature review focusing on neutrophil and Th17 cell functions.
- Analysis of their interactions in different pathophysiological contexts.
- Compilation of data on IL-17A-targeting therapies.
Main Results:
- Neutrophils and Th17 cells exhibit significant interactions influencing adaptive immunity.
- Both cell types are implicated in diverse diseases, including infections, autoimmune conditions, and cancer.
- Interleukin 17 (IL-17) pathway modulation is a key therapeutic strategy.
Conclusions:
- Understanding neutrophil-Th17 cell interplay is crucial for comprehending immune responses and diseases.
- Targeting the IL-17 pathway offers potential therapeutic avenues for various inflammatory and autoimmune conditions.
- Further research into these interactions can inform novel treatment strategies.
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