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Link between the skin and autism spectrum disorder
Mao-Qiang Man1,2,3, Shuyun Yang4, Theodora M Mauro2,3
1Dermatology Hospital, Southern Medical University, Guangzhou, China.
Frontiers in Psychiatry
|November 3, 2023
Summary
Autism spectrum disorder (ASD) may be linked to skin inflammation and dysfunction. Treating skin conditions and improving epidermal function shows potential for managing ASD symptoms.
Area of Science:
- Neurology
- Dermatology
- Immunology
Background:
- Autism spectrum disorder (ASD) is a common neurological condition with complex etiologies.
- Evidence suggests a link between cutaneous inflammation and ASD, with higher prevalence in individuals with inflammatory dermatoses.
- Recent research indicates a connection between epidermal dysfunction and ASD.
Purpose of the Study:
- To summarize current evidence on the association between skin conditions and ASD.
- To explore the pathogenic role of cutaneous inflammation and epidermal dysfunction in ASD.
Main Methods:
- Review of current scientific literature and studies.
- Analysis of findings from murine models of ASD.
- Examination of clinical observations in children with ASD.
Main Results:
- Individuals with ASD show a higher prevalence of inflammatory dermatoses.
- Murine models with ASD exhibit epidermal dysfunction and increased proinflammatory cytokines in skin and brain.
- Children with ASD present with altered epidermal function, and improvements alleviate some symptoms.
Conclusions:
- Cutaneous dysfunction appears to play a pathogenic role in ASD.
- Improving epidermal function or treating inflammatory dermatoses may offer alternative management strategies for ASD.
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