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Related Experiment Videos

Calcium and morphogenetic fields.

L F Jaffe

    Ciba Foundation Symposium
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Polarizing fucoid eggs establish a developmental axis via a steady calcium ion current. This current creates a calcium gradient (pCa) essential for axis formation, suggesting similar mechanisms in other biological systems.

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    Area of Science:

    • Developmental biology
    • Cellular physiology
    • Biophysics

    Background:

    • Establishing a developmental axis is crucial for organismal development.
    • Calcium ions play significant roles in various cellular processes, including cell polarity and axis formation.
    • Previous hypotheses suggested metabolic gradients influence developmental polarity.

    Purpose of the Study:

    • To investigate the role of calcium ion currents in establishing the developmental axis of fucoid eggs.
    • To explore the formation of calcium gradients (pCa) as a mechanism for axis determination.
    • To review evidence for calcium currents in other developmental contexts and propose new measurement techniques.

    Main Methods:

    • Experiments using polarizing fucoid eggs to observe calcium ion currents.

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  • Analysis of calcium gradients (pCa) within the egg.
  • Review of existing evidence for developmental calcium currents using vibrating extracellular voltage electrodes.
  • Discussion of progress in visualizing intracellular pCa gradients.

    • Main Results:

    • Experiments indicate a steady calcium ion current drives axis establishment in fucoid eggs.
    • This calcium current appears to establish a pCa gradient, contributing to axis formation.
    • The study suggests that previously proposed metabolic gradients may involve pCa gradients.

    Conclusions:

    • Calcium ion currents and their resultant pCa gradients are integral to developmental axis formation in fucoid eggs.
    • The findings support the extension of this model to other developmental phenomena, such as Child's metabolic gradients and Bünning's cell divisions.
    • Future research directions include developing vibrating extracellular pCa electrodes and direct visualization of intracellular pCa gradients.