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Guidelines and Experience Using Imaging Biomarker Explorer IBEX for Radiomics
Published on: January 8, 2018
Current Status of Cancer Genomics and Imaging Phenotypes: What Radiologists Need to Know.
Eva Mendes Serrão1, Maximiliano Klug1, Brian M Moloney1
1From the Joint Department of Medical Imaging, University Medical Imaging Toronto, University Health Network, University of Toronto, 585 University Ave, Toronto, ON, Canada M5G 2N2 (E.M.S., A.J., M.A.H., X.L.); Division of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel (M.K.); Department of Radiology, The Christie NHS Trust, Manchester, England (B.M.M.); Department of Radiology, Breast Imaging Service, Memorial Sloan-Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY (R.L.G., K.P.); Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, Mich (G.L.); Lunenfeld Tanenbaum Research Institute, Sinai Health System, Mount Sinai Hospital, Toronto, Ontario, Canada (M.A.H.); and Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.B.S.).
Radiologists must understand cancer genomics and epigenomics to improve patient care. Integrating these concepts enhances imaging interpretations and facilitates precision oncology through radiogenomics.
Area of Science:
- Oncology
- Radiology
- Genomics
- Epigenomics
Background:
- Cancer genomics and epigenomics have transformed oncology and precision medicine.
- Understanding tumor biology and heterogeneity is crucial for personalized care.
- Genomic sequencing drives new classifications, biomarkers, and targeted cancer therapies.
Purpose of the Study:
- To familiarize radiologists with essential genomics and epigenomics concepts.
- To demonstrate the integration of these molecular insights into clinical radiology practice.
- To highlight the role of radiogenomics in advancing cancer diagnosis and treatment.
Main Methods:
- Review of fundamental concepts in cancer genomics and epigenomics.
- Analysis of common genetic alterations in various cancers.
- Discussion of the impact of these molecular concepts on organ-system-specific imaging interpretations.
Main Results:
- Genomic insights offer deeper understanding of tumor biology and heterogeneity.
- Radiologists can enhance imaging specificity and clinical dialogue by incorporating molecular data.
- The review provides a case-based approach linking molecular alterations to imaging findings.
Conclusions:
- Familiarity with cancer genomics and epigenomics is essential for modern radiologists.
- Integrating radiogenomics can lead to more meaningful imaging interpretations and patient-centric care.
- This knowledge is vital for driving innovation in imaging biomarkers and molecular imaging.
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