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Changes in distal esophageal function in response to cooling.

M D Kaye, A E Kilby, P C Harper

    Digestive Diseases and Sciences
    |January 1, 1987
    PubMed
    Summary

    Drinking iced water temporarily impairs esophageal motility and lower esophageal sphincter function in healthy individuals and those with esophageal spasm. This effect is not altered by isosorbide denitrate.

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    Area of Science:

    • Gastroenterology
    • Physiology

    Background:

    • Esophageal motility disorders can cause significant discomfort.
    • The impact of cold stimuli on esophageal function requires further elucidation.

    Purpose of the Study:

    • To investigate the effects of cold water on esophageal motility.
    • To assess the influence of isosorbide denitrate on these responses.

    Main Methods:

    • Nine healthy subjects and two patients with esophageal spasm ingested water at room temperature and 0°C.
    • Measurements of esophageal contractions and lower esophageal sphincter function were taken before and after sublingual isosorbide denitrate administration.

    Main Results:

    • Iced water reduced the strength, increased duration, and decreased velocity of distal esophageal contractions.
    • Cold water transiently reduced lower esophageal sphincter contraction force but did not affect relaxation.
    • Isosorbide denitrate did not alter esophageal responses to cold water in either group.

    Conclusions:

    • Cold exposure induces a temporary state of reduced motility in the distal esophagus and lower esophageal sphincter.
    • These findings suggest a link between cold-induced chest pain and esophageal distension, even in patients with motor disorders.

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