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Updated: Jul 11, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
A rare case of skin metastasis from a chordoma
Maria Vaz Cunha1, Joana Carvalho Mendonca, Marta Silva Oliveira
1General and Family Medicine, Unidade de Saude Familiar (USF) Ara de Trajano, Guimaraes, Portugal.
Abstract:
Chordoma is an uncommon, indolent malignant tumor arising from notochordal remnants. The incidence of distant metastasis varies between 30 and 40% in different series. Even though local involvement of the skin by direct invasion of chordoma is common, distant skin metastasis are rare, with less than 30 cases reported in the literature. The present clinical case illustrates the slow-growing natural history of a sacral chordoma, which evolved with lung metastasis, followed three years later by skin metastasis, thus giving us the opportunity to review the diagnostic approach, as well as the clinical and histopathological characteristics of this rare tumor.
Insights
Chordoma, a rare bone cancer, can spread to distant skin sites, though infrequently. This case highlights a sacral chordoma
Area of Science:
- Oncology
- Pathology
Background:
- Chordoma is a rare, slow-growing malignant tumor originating from notochordal remnants.
- Distant metastasis occur in 30-40% of chordoma cases.
- While local skin invasion is common, distant skin metastasis are exceptionally rare.
Observation:
- This clinical case presents a sacral chordoma with a slow-growing progression.
- The tumor initially metastasized to the lungs.
- Subsequently, three years later, skin metastasis developed.
Findings:
- The case illustrates a rare instance of distant skin metastasis from a sacral chordoma.
- It emphasizes the indolent and slow-growing nature of chordoma.
- The occurrence of both lung and subsequent skin metastasis was observed.
Implications:
- This case underscores the importance of considering rare metastatic patterns in chordoma.
- It provides an opportunity to review diagnostic strategies for chordoma.
- Understanding the clinical and histopathological features of rare presentations is crucial for patient management.
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