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Related Concept Videos

Mismatch Repair01:36

Mismatch Repair

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Mismatch Repair01:36

Mismatch Repair

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Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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Imperfections in Crystal Structure: Stoichiometric Point Defects01:26

Imperfections in Crystal Structure: Stoichiometric Point Defects

Schottky defects arise when some lattice points in a crystal, such as those in NaCl, remain unoccupied, creating lattice vacancies without disturbing the overall electrical neutrality of the crystal. This defect is common in ionic crystals where the positive and negative ions are similar in size, as seen in sodium chloride and cesium chloride. The presence of Schottky defects enables the crystal to conduct electricity to a small extent through an ionic mechanism. Electric fields cause nearby...
Imperfections in Crystal Structure: Non-Stoichiometric Defects01:29

Imperfections in Crystal Structure: Non-Stoichiometric Defects

Non-stoichiometric defects refer to a type of defect in the crystal structure of a compound where the ratio of its constituent elements deviates from the ideal stoichiometric ratio. There are two main types of non-stoichiometric defects: metal excess defects and metal deficiency defects.Metal excess defects occur when there is a slight surplus of metal ions than what is required by the stoichiometric ratio of the compound. For example, heating a sodium chloride crystal in sodium vapor results...

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Articles linked to this work by shared authors, journal, and citation graph.

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Operative Orthopadie und Traumatologie·2026
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[General principles of biopsy technique and approaches in soft tissue and bone sarcomas].

Operative Orthopadie und Traumatologie·2026
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[Tumour-related extra-articular knee joint resection].

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Diagnosis of periprosthetic loosening of total hip and knee arthroplasty using <sup>68</sup>Gallium-Zoledronate PET/CT.

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Explant analysis and implant registries are both needed to further improve patient safety.

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Related Experiment Video

Updated: Jul 12, 2026

Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty
09:31

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[Acetabular metastatic defect reconstruction using the modular revision support cup MRS-C].

S Koob1, H Kohlhof2, T M Randau3

  • 1Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland. Sebastian.Koob@ukbonn.de.

Operative Orthopadie Und Traumatologie
|November 3, 2023
PubMed
Summary

This study demonstrates the effectiveness of bone cement-augmented revision support cups in stabilizing metastatic acetabular defects, enabling patient remobilization. The implants showed high survivability, improving quality of life for advanced cancer patients.

Keywords:
Compound osteosynthesisHip fractureMetastatic bone diseasePalliative surgeryPathologic fracture

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Area of Science:

  • Orthopedic oncology
  • Reconstructive surgery
  • Biomaterials engineering

Context:

  • Metastatic acetabular defects pose significant challenges in oncological patients.
  • Current treatment options often focus on palliative care, with limited focus on functional restoration.
  • Advanced cancer stages necessitate innovative solutions for skeletal reconstruction and patient mobility.

Purpose:

  • To evaluate the efficacy of a bone cement-augmented revision support cup for stabilizing metastatic acetabular defects.
  • To assess the impact of this surgical technique on the remobilization and quality of life in oncological patients.
  • To determine the implant survivability and functional outcomes in patients with advanced cancer.

Summary:

  • Fourteen patients with metastatic acetabular defects (MAC 2-4) and medium-to-long-term survival prognosis underwent acetabular reconstruction using a cement-augmented revision support cup.
  • The surgical technique involved curettage, reaming, cement augmentation, and implant insertion, followed by modular inlay or dual mobility system.
  • Postoperative management included weight-bearing as tolerated, adjuvant radiation, and continued systemic therapy, with a mean Harris Hip Score improvement of 23.2 and a mean survival of 9.7 months.

Impact:

  • The study highlights the potential of cement-augmented revision support cups to improve functional outcomes and enable remobilization in oncological patients with acetabular metastases.
  • The implants demonstrated high survivability (13/14) in this challenging patient population, suggesting a favorable risk-benefit profile.
  • This approach offers a viable option for improving the quality of life for patients with advanced cancer and skeletal involvement.