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Versatile Injectable Carboxymethyl Chitosan Hydrogel for Immediate Hemostasis, Robust Tissue Adhesion Barrier, and
Hao Guo1, Haifeng Shen1, Juping Ma1
1State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
ACS Applied Materials & Interfaces
|November 3, 2023
Summary
A novel injectable hydrogel effectively stops bleeding and promotes healing for iatrogenic ulcers after endoscopic submucosal dissection (ESD) surgery. This advanced material offers excellent biocompatibility and antibacterial properties, improving patient outcomes.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Gastroenterology
Background:
- Iatrogenic ulcers from endoscopic submucosal dissection (ESD) pose bleeding risks.
- Effective hemostatic and wound healing solutions are needed for post-ESD complications.
Purpose of the Study:
- To develop and characterize an injectable, shear-thinning hydrogel for treating ESD-induced ulcers.
- To evaluate the hydrogel's hemostatic, antibacterial, and biocompatibility properties.
Main Methods:
- Fabrication of a hydrogel via electrostatic interactions and hydrogen bonding.
- Comprehensive characterization including rheology, injectability, microstructure, and degradation.
- Assessment of antibacterial efficacy, hemostasis, biocompatibility, and in vivo performance.
Main Results:
- The hydrogel demonstrated optimal rheological, film-forming, and adhesion properties.
- It exhibited significant hemostatic performance and antibacterial activity against E. coli and S. aureus.
- In vivo studies and biocompatibility tests confirmed its safety and efficacy for wound healing.
Conclusions:
- The developed hydrogel is a promising injectable material for endoscopic treatment of ESD-induced ulcers.
- Its unique properties support wound healing and minimize bleeding risks.
- This innovation offers a potential solution for managing post-ESD complications.
