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Updated: Jul 11, 2025

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Published on: March 30, 2019
Transbrachial Artery as Single or Combined Approach for Complex Interventions in Patients with Peripheral Artery
Jiawen Wu1, Jinyan Xu2, Qingyuan Yu2
1Department of Vascular Surgery, Changhai Hospital, Navy Military Medical University, Shanghai City, China; Department of Vascular Surgery, The Quzhou Affiliated Hospital of Wenzhou Medical Univsersity, Quzhou People's Hospital, Quzhou City, Zhejiang Province, China.
Insights
The transbrachial approach is a safe method for complex peripheral artery disease interventions. Improved blood pressure control significantly reduces brachial access complications.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Endovascular Therapy
Background:
- Peripheral artery disease (PAD) management often requires complex endovascular interventions.
- The transbrachial approach offers an alternative access route for these procedures.
Purpose of the Study:
- To evaluate the safety and efficacy of the transbrachial approach for PAD interventions.
- To identify predictors of adverse events associated with brachial artery access.
Main Methods:
- Retrospective analysis of 169 patients with PAD undergoing transbrachial endovascular therapy (March 2011-April 2021).
- Procedures were performed as single or combined approaches.
- Univariate and multivariate analyses assessed predictors of brachial puncture site adverse events.
Main Results:
- Hypertension was identified as an independent predictor of brachial puncture site adverse events (OR, 4.76; P=.016).
- Overall complication rate was 15.4% (26/169), with 6 major and 20 minor events.
- Vascular closure device (VCD) use was associated with no major entry-site complications.
Conclusions:
- The transbrachial approach is a safe and effective option for complex PAD interventions.
- Effective blood pressure management is crucial for minimizing brachial access complications.
Background:
This study aimed to assess the safety and efficacy of the transbrachial approach as a single or combined procedure for complex interventions in peripheral artery disease (PAD).
Methods:
Between March 2011 and April 2021, 169 patients with PAD underwent endovascular therapy via the transbrachial approach as a single or dual procedure. Univariate and multivariate analyses were performed to evaluate the predictors of adverse events at the brachial puncture site. All demographic, clinical, and perioperative data were acquired from electronic medical records and retrospectively analyzed.
Results:
Brachial artery access was used alone and in combination in 87 and 82 patients, respectively. Patients in the combined-approach group underwent more intraoperative stent implantations and had more vascular closure devices (VCD). Multivariate logistic regression analysis revealed that hypertension was an independent factor for higher rates of brachial puncture site adverse events (odds ratio, 4.76; 95% confidence interval, 1.33-16.97; P = 0.016). Brachial artery access-site complications occurred in 26 patients, including 6 (23.1%) major and 20 (76.9%) minor entry-site complications. Entry-site complications were observed in 21 (16.8%) and 5 (11.4%) patients assigned to manual compression and VCD groups, respectively. There were no significant intergroup differences in the incidence of major or minor complications. Interestingly, patients assigned to the VCD group did not experience major entry-site complications.
Conclusions:
The transbrachial approach, as a single or combined procedure, is a safe alternative to complex interventions in patients with PAD. Complications of brachial access progressively decrease with improved blood pressure control.
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