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Dose-response association between cardiovascular health and mortality in cancer survivors

Rubén López-Bueno1, Lin Yang2, Joaquín Calatayud3

  • 1Department of Physical Medicine and Nursing, University of Zaragoza, Zaragoza, Spain; Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, Valencia, Spain; National Research Centre for the Working Environment, Copenhagen, Denmark.

Current Problems in Cardiology
|November 3, 2023
PubMed

Insights

Improving cardiovascular health (CVH) significantly lowers mortality risk in cancer survivors. Higher scores on the American Heart Association´s Life´s Essential 8 (LE8) are linked to reduced all-cause and cardiovascular disease (CVD) deaths, but not cancer deaths.

Area of Science:

  • Cardiovascular health research
  • Cancer survivorship studies
  • Public health and epidemiology

Background:

  • Limited understanding of cardiovascular health (CVH) impact on mortality in cancer survivors.
  • Need to establish dose-response relationships for all-cause, cardiovascular disease (CVD), and cancer mortality.

Purpose of the Study:

  • To investigate the dose-response association between CVH and mortality risks in US adult cancer survivors.
  • To evaluate the impact of the American Heart Association´s Life´s Essential 8 (LE8) score on mortality outcomes.

Main Methods:

  • Utilized data from 1701 US adult cancer survivors from the National Health and Nutrition Examination Survey (NHANES) (2007-2018).
  • Employed the American Heart Association´s Life´s Essential 8 (LE8) as a proxy for cardiovascular health.
  • Applied restricted cubic spline models to analyze dose-response associations.

Main Results:

  • A nearly inverse linear association was found between LE8 scores and all-cause mortality, with significant risk reductions observed.
  • An inverse curvilinear association between LE8 scores and CVD mortality showed significant risk reductions.
  • No significant dose-response association was identified between LE8 scores and cancer mortality.

Conclusions:

  • Higher cardiovascular health, as measured by LE8, is associated with reduced all-cause and CVD mortality in cancer survivors.
  • The findings suggest potential for substantial public health impact through CVH improvement initiatives.
  • Further research may explore specific interventions to enhance CVH and mitigate mortality risks in this population.
Abstract

Keywords:
CardiologyLife expectancyLifestyleOncologyPreventive medicinePublic health

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