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[Translated article] Immunotherapy and Targeted Therapy in Patients With Advanced Melanoma and the V600 BRAF
D Moreno-Ramírez1, A Fernández-Orland1, L Ferrándiz1
1Unidad de Melanoma, Servicio de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Virgen Macarena, Seville, Spain.
Actas Dermo-Sifiliograficas
|November 3, 2023
Summary
Systemic treatments like immunotherapy and targeted therapy improve survival for advanced melanoma. An algorithm helps guide treatment decisions for BRAF-mutated melanoma, balancing efficacy and toxicity.
Area of Science:
- Oncology
- Dermatology
- Medical Research
Background:
- Advanced melanoma treatment has evolved with immunotherapy and targeted therapy.
- BRAF mutations are present in 50% of melanoma patients, influencing treatment selection.
- Optimal sequencing of systemic therapies requires consideration of drug, tumor, and patient factors.
Approach:
- Literature review on immunotherapy and targeted therapy in melanoma.
- Development of a decision-making algorithm for first-line treatment.
- Analysis of survival outcomes, drug efficacy, and toxicity profiles.
Key Points:
- Immunotherapy (ipilimumab/nivolumab) offers best survival but high toxicity.
- Targeted therapy presents a favorable option in specific clinical scenarios.
- BRAF mutation status is critical for selecting advanced melanoma treatments.
Conclusions:
- A structured approach is needed to optimize systemic therapy sequencing.
- The presented algorithm aids clinicians in choosing between immunotherapy and targeted therapy.
- Personalized treatment strategies are essential for improving outcomes in advanced melanoma.
Keywords:
Adjuvant treatmentAnti-CTLA4Anti-PD1BRAF inhibitorsBRAF-MEK inhibitorsCTLA4 inhibitorsImmunotherapyInhibidores de BRAFInhibidores de BRAF-MEKInmunoterapiaMelanomaNeoadjuvant therapyPD1 inhibitorsTargeted therapyTerapias dirigidasTratamiento adyuvanteTratamiento neoadyuvanteMore Related Videos
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