A review on solution- and vapor-responsive sensors for the detection of phthalates

Phthalic acid esters, largely referred to as phthalates, are today acknowledged as important pollutants used in the manufacture of polyvinyl chloride (PVC)-based plastics, whose use extends to almost every aspect of modern life. The risk of exposure to phthalates is particularly relevant as high concentrations are regularly found in drinking water, food-contact materials and medical devices, motivating an immense body of research devoted to methods for their detection in liquid samples. Conversely, phthalate vapors have only recently been acknowledged as potentially important atmospheric pollutants and as early fire indicators; additionally, deposition of these vapors can pose significant problems to the proper functioning of spacecraft and diverse on-board devices, leading to major space agencies recognizing the need of developing vapor-responsive phthalate sensors. In this manuscript we present a literature survey on solution- and vapor-responsive sensors and analytical assays for the detection of phthalates, providing a detailed analysis of a vast array of analytical data to offer a clear idea on the analytical performance (limits of detection and quantification, linear range) and advantages provided by each class of sensor covered in this review (electrochemical, optical and vapor-responsive) in the context of their potential real-life applications; the manuscript also gives detailed fundamental information on the various physicochemical responses exploited by these sensors and assays that could potentially be harnessed by new researchers entering the field.