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KDM4B: A promising oncology therapeutic target

Fangjing Ni1, Heting Tang1, Siteng Cheng1

  • 1Department of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.

Cancer Science
|November 3, 2023
PubMed

Insights

Lysine demethylases (KDMs) are crucial in cancer development. This review details KDM4B

Area of Science:

  • Epigenetics and Molecular Biology
  • Cancer Research
  • Biochemistry

Background:

  • Epigenetic modifications, including histone demethylation, are vital in tumor pathogenesis.
  • Lysine demethylases (KDMs), particularly the KDM4 family (JMJD2), regulate critical cellular processes like gene transcription, apoptosis, and DNA repair.
  • The KDM4 family plays a significant role in cell cycle regulation, DNA repair, signaling pathways, and tumor progression.

Purpose of the Study:

  • To provide a comprehensive review of KDM4B, a key member of the KDM4 gene family.
  • To elucidate the structure, mechanism, and function of KDM4B.
  • To critically analyze the role of KDM4B in tumorigenesis and explore potential therapeutic strategies targeting KDM4B.

Main Methods:

  • Literature review and critical analysis of existing research on KDM4B.
  • Examination of KDM4B's structure and biochemical mechanisms.
  • Synthesis of data on KDM4B's involvement in cancer development and therapeutic targeting.

Main Results:

  • KDM4B is integral to regulating gene transcription, DNA repair, and cell cycle progression.
  • Dysregulation of KDM4B is implicated in various aspects of tumor formation and development.
  • Current research highlights KDM4B as a promising target for novel cancer therapies.

Conclusions:

  • Understanding KDM4B's molecular mechanisms is crucial for cancer research.
  • KDM4B's multifaceted role in tumorigenesis presents significant therapeutic opportunities.
  • Targeting KDM4B offers a potential strategy for developing new anti-cancer treatments.
Keywords:
KDM4Bcancer therapeutic targetshistone demethylaseoncologyreview

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