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Monocyte function in psoriasis.

M Bar-Eli, R Gallily, H A Cohen

    The Journal of Investigative Dermatology
    |August 1, 1979
    PubMed
    Summary
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    Monocytes from psoriasis patients exhibit enhanced phagocytosis and bacterial killing. This suggests immune cell dysfunction in psoriasis may extend beyond skin cells, potentially linked to cyclic nucleotide imbalances.

    Area of Science:

    • Immunology
    • Dermatology
    • Cell Biology

    Background:

    • Psoriasis is a chronic inflammatory skin disease.
    • Immune cell dysfunction is implicated in psoriasis pathogenesis.
    • Previous research suggests abnormalities in epidermal cells.

    Purpose of the Study:

    • To investigate monocyte function in psoriatic patients.
    • To compare phagocytic and bactericidal capacities of monocytes from psoriatic patients and healthy controls.
    • To explore the role of cyclic nucleotides in monocyte dysfunction.

    Main Methods:

    • Isolation of peripheral blood monocytes from psoriatic patients and healthy subjects.
    • Assay of phagocytic capacity using radiolabeled bacteria (Shigella flexneri, Staphylococcus albus).

    Related Experiment Videos

  • Measurement of bactericidal capacity against Staphylococcus albus.
  • Assessment of antibody-dependent cellular cytotoxicity (ADCC) against EL4 tumor cells.

    • Main Results:

    • Monocytes from psoriatic patients showed significantly higher phagocytic capacity (36-40%) for both bacterial species compared to controls.
    • Psoriatic monocytes exhibited a 2-to-4-fold increase in bactericidal capacity against Staphylococcus albus.
    • Diphylline treatment did not alter monocyte bactericidal capacity.
    • ADCC activity was similar between psoriatic patients and controls.

    Conclusions:

    • Psoriatic monocytes display heightened phagocytic and bactericidal functions.
    • These monocyte abnormalities may stem from a decreased cyclic adenosine monophosphate/cyclic guanosine monophosphate (cAMP/cGMP) ratio.
    • The findings suggest that immune cell dysfunction in psoriasis is not limited to epidermal cells.