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Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
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The role of lactate in cardiovascular diseases

Jun Ouyang1, Hui Wang2, Jiangnan Huang3

  • 1Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Cell Communication and Signaling : CCS
|November 4, 2023
PubMed

Insights

Lactate, a byproduct of glycolysis, plays a key role in cardiovascular diseases like heart attack and heart failure. Understanding lactate

Area of Science:

  • Biochemistry
  • Cardiology
  • Metabolic research

Background:

  • Cardiovascular diseases (CVDs) are a leading global health concern, encompassing conditions such as acute myocardial infarction (AMI), heart failure, atrial fibrillation (AF), and atherosclerosis.
  • Metabolic alterations, particularly in glycolysis, are frequently observed in the pathophysiology of these cardiovascular conditions.
  • Lactate, the end-product of glycolysis, was historically overlooked but is now recognized for its significant biological functions.

Discussion:

  • The role of lactate in cardiovascular disease is increasingly appreciated, moving beyond its traditional view as a mere metabolic waste product.
  • Research highlights lactate's involvement in the complex pathophysiological processes underlying various cardiovascular ailments.
  • Dysregulation of lactate metabolism, production, and transport is implicated in the progression of cardiovascular diseases.

Key Insights:

  • Lactate is emerging as a critical factor in cardiovascular disease development and progression.
  • Altered glycolysis and subsequent changes in lactate levels are hallmarks of cardiovascular pathologies.
  • Targeting lactate pathways presents a promising therapeutic avenue for cardiovascular conditions.

Outlook:

  • Future research should focus on elucidating the precise mechanisms by which lactate influences cardiovascular health and disease.
  • Modulating lactate production, transport, and circulating levels may offer novel treatment strategies for cardiovascular diseases.
  • Exploring lactate's role in cardiovascular disease can provide insights into other related metabolic disorders.

Keywords:
Acute myocardial infarctionAtherosclerosisAtrial fibrillationHeart failureLactateLactylation

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