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Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
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Risk factors for cough after pulmonary resection
Yongming Wu1,2, Wenpeng Song1,2, Dongmei Zhu3,4
1Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
World Journal of Surgical Oncology
|November 4, 2023
Summary
This meta-analysis identified key risk factors for post-pulmonary resection cough. Female sex, preoperative cough, right lung surgery, lobectomy, specific lymph node dissections, stapler closure, and acid reflux increase cough risk, while younger age may be protective.
Area of Science:
- Thoracic Surgery
- Pulmonology
- Medical Research
Background:
- Postoperative cough is a common complication following pulmonary resection.
- Identifying risk factors is crucial for improving patient outcomes and developing targeted interventions.
Purpose of the Study:
- To conduct a meta-analysis to identify independent risk factors associated with cough after pulmonary resection.
- To synthesize evidence from multiple studies to provide a comprehensive understanding of cough etiology post-surgery.
Main Methods:
- A systematic literature search was performed across major databases (PubMed, Embase, Web of Science, etc.) up to November 2022.
- Nineteen studies involving 4755 patients were included in the meta-analysis.
- Statistical heterogeneity was assessed using Q tests and I² statistic, with odds ratios (OR) combined using the inverse variance method.
Main Results:
- The incidence of postoperative cough ranged from 21.1% to 55.8%.
- Independent risk factors identified include: younger age (protective), female sex, preoperative cough, right lobe operation, lobectomy, subcarinal and mediastinal lymph node dissection, stapler closure of bronchial stump, peritracheal lymph node resection, and postoperative acid reflux.
Conclusions:
- Several factors significantly increase the risk of developing cough after pulmonary resection.
- Preoperative cough, specific surgical techniques (lobectomy, lymph node dissection, stapler closure), and postoperative acid reflux are strong predictors.
- Younger age appears to be a protective factor against developing postoperative cough.
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