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Related Experiment Videos

Components of the Goeckerman regimen.

M J Le Vine, H A White, J A Parrish

    The Journal of Investigative Dermatology
    |August 1, 1979
    PubMed
    Summary

    Ultraviolet radiation improves psoriasis but requires a tar or lubricant. Crude coal tar offers no additional benefit over lubricants when used with UV radiation for psoriasis treatment.

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    Area of Science:

    • Dermatology
    • Phototherapy
    • Cutaneous Oncology

    Background:

    • The Goeckerman regimen, combining tar and ultraviolet radiation, is a known psoriasis therapy.
    • The individual contributions of tar and ultraviolet radiation to treatment efficacy remain unclear.

    Purpose of the Study:

    • To elucidate the specific roles of ultraviolet radiation and tar preparations in psoriasis treatment.
    • To compare the efficacy of different tar formulations and lubricant bases in conjunction with ultraviolet radiation.

    Main Methods:

    • A bilateral comparison study involving 30 hospitalized patients with chronic stable plaque-type psoriasis vulgaris.
    • Controlled exposure to ultraviolet radiation (290-400 nm) and various tar preparations/lubricant vehicles, both separately and in combination.

    Main Results:

    • Maximal ultraviolet radiation alone improved psoriasis significantly but did not achieve complete clearance.
    • The addition of tar preparations or lubricant bases to ultraviolet radiation was necessary for marked improvement.
    • Crude coal tar (5%) showed no significant advantage over a lubricant base when combined with ultraviolet radiation.
    • No specific tar preparation demonstrated consistent superiority over others.

    Conclusions:

    • Both ultraviolet radiation and a vehicle (tar or lubricant) are essential for effective psoriasis treatment.
    • The specific type of tar preparation does not appear to significantly impact treatment outcomes compared to a lubricant base.

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