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Online remote behavioural intervention for tics in 9- to 17-year-olds: the ORBIT RCT with embedded process and
Chris Hollis1,2,3,4, Charlotte L Hall1,2,3, Kareem Khan1,3
1NIHR MindTech MedTech Co-operative, Institute of Mental Health, School of Medicine, University of Nottingham, Nottingham, UK.
Health Technology Assessment (Winchester, England)
|November 4, 2023
Summary
Online behavioral therapy effectively reduces tics in young people with tic disorders, offering lasting benefits up to 18 months. This therapist- and parent-supported intervention is both clinically and cost-effective.
Area of Science:
- Clinical Psychology
- Child Psychiatry
- Health Economics
Background:
- Behavioral therapy for tics is challenging to access.
- Effectiveness of online delivery for tic disorders is not well understood.
Purpose of the Study:
- To assess the clinical and cost-effectiveness of an online, therapist- and parent-supported therapy for young people with tic disorders.
Main Methods:
- A single-blind, parallel-group, randomized controlled trial with 224 participants (aged 9-17) with Tourette syndrome or chronic tic disorder.
- Intervention: 10 weeks of online, remotely delivered, therapist-supported exposure and response prevention therapy.
- Control: Online psychoeducation. Outcomes assessed at 3, 6, 12, and 18 months post-randomization.
Main Results:
- The online therapy group showed a significant reduction in tic severity (Yale Global Tic Severity Scale) compared to the control group, with sustained effects up to 18 months.
- The intervention was found to be clinically effective (mean difference -2.29 at 3 months) and cost-effective (mean incremental cost per QALY gained £16,708).
- Parental engagement was linked to better child engagement and clinical outcomes.
Conclusions:
- Online, therapist-supported behavioral therapy is a clinically and cost-effective treatment for reducing tics in young people.
- The benefits of this online intervention are durable, lasting up to 18 months post-treatment.
- Further research should compare online to face-to-face therapy and explore clinical integration.

