LncRNA-miRNA interaction is involved in colorectal cancer pathogenesis by modulating diverse signaling pathways

Area of Science:

• Molecular Biology
• Genetics
• Oncology

Background:

• Long non-coding RNAs (lncRNAs) act as molecular sponges or directly interact with microRNAs (miRNAs).
• MicroRNAs (miRNAs) are crucial regulators of gene expression, including oncogenes and tumor suppressor genes.
• Dysregulation of miRNAs is implicated in the development and progression of various cancers, including colorectal cancer (CRC).

Purpose of the Study:

• To explore the therapeutic potential of targeting the lncRNA-miRNA axis in colorectal cancer (CRC).
• To identify key challenges hindering the clinical application of lncRNA-miRNA-based therapies for CRC.

Main Methods:

• The study reviews the mechanisms by which lncRNAs and miRNAs interact and influence gene expression.
• It analyzes the role of the lncRNA-miRNA axis in the context of cancer-related genes and CRC pathogenesis.
• The research synthesizes current knowledge on therapeutic strategies targeting this axis.

Main Results:

• LncRNAs can modulate miRNA activity through sponging or direct interaction, impacting cancer-related gene expression.
• miRNA dysregulation is a significant factor in CRC onset and progression.
• Targeting the lncRNA-miRNA axis presents a promising avenue for CRC treatment.

Conclusions:

• The lncRNA-miRNA axis holds significant therapeutic potential for colorectal cancer (CRC).
• Overcoming challenges related to targeting specificity, delivery, resistance, safety, and cost-effectiveness is crucial for clinical translation.
• Further research is needed to optimize these strategies for improved CRC patient outcomes.