Implications of biotic factors for toxicity testing in laboratory studies

There is an emerging call from scientists globally to advance the environmental relevance of laboratory studies, particularly within the field of ecotoxicology. To answer this call, we must carefully examine and elucidate the shortcomings of standardized toxicity testing methods that are used in the derivation of toxicity values and regulatory criteria. As a consequence of rapidly accelerating climate change, the inclusion of abiotic co-stressors are increasingly being incorporated into toxicity studies, with the goal of improving the representativeness of laboratory-derived toxicity values used in ecological risk assessments. However, much less attention has been paid to the influence of biotic factors that may just as meaningfully impact our capacity to evaluate and predict risks within impacted ecosystems. Therefore, the overarching goal is to highlight key biotic factors that should be taken into consideration during the experimental design and model selection phase. SYNOPSIS: Scientists are increasingly finding that lab reared results in toxicology might not be reflective of the external wild environment, we highlight in this review some key considerations when working between the lab and field.