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Systemic inflammation and oxidative stress markers in patients with unipolar and bipolar depression: A large-scale

Yanyan Wei1, Huanqin Gao1, Yanhong Luo2

  • 1Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China.

Journal of Affective Disorders
|November 4, 2023
PubMed

Insights

Inflammation markers like neutrophil/HDL ratio (NHR) and monocyte/HDL ratio (MHR) differ between unipolar depression (UD) and bipolar depression (BD). These markers also distinguish psychotic from non-psychotic UD patients, indicating their role in depression pathophysiology.

Area of Science:

  • Biochemistry
  • Psychiatry
  • Immunology

Background:

  • Neutrophil/HDL ratio (NHR), lymphocyte/HDL ratio (LHR), monocyte/HDL (MHR), platelet/HDL ratio (PHR), neutrophil/ALB ratio (NAR), and platelet/ALB ratio (PAR) are established markers of systemic inflammation and oxidative stress.
  • Limited research has explored the association of these inflammation and oxidative stress markers with unipolar depression (UD) and bipolar depression (BD), particularly concerning psychotic symptoms.

Purpose of the Study:

  • To investigate the association of NHR, LHR, MHR, PHR, NAR, and PAR with UD and BD.
  • To examine the role of these markers in differentiating between UD and BD.
  • To analyze the relationship between these markers and psychotic symptoms in UD and BD patients.

Main Methods:

  • A cross-sectional study involving 6297 UD patients, 1828 BD patients, and 7630 healthy controls.
  • Comparison of NHR, LHR, MHR, PHR, NAR, and PAR levels across diagnostic groups (UD, BD, healthy controls).
  • Analysis of influencing factors for UD, BD, and psychotic symptoms, including these specific ratios.

Main Results:

  • Distinct variation patterns were observed for these ratios across diagnostic groups.
  • The BD group showed higher NHR, LHR, MHR, NAR, and lower PAR compared to UD and healthy controls.
  • The UD group exhibited higher MHR than healthy controls. Psychotic UD patients had higher NHR, LHR, MHR, and NAR than non-psychotic UD patients. Higher LHR, MHR, NAR, and lower PAR were risk factors for BD compared to UD.

Conclusions:

  • Significant differences in inflammation and oxidative stress profiles exist between UD and BD patients.
  • These markers differentiate between individuals with and without psychotic symptoms within UD and BD.
  • Inflammation and oxidative stress play a crucial role in the pathophysiology of UD and BD.
Abstract

Keywords:
Bipolar depressionInflammationNeutrophil/HDL ratioOxidative stressPsychotic symptomsUnipolar depression

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